Talerman A, van der Pompe W B, Haije W G, Baggerman L, Boekestein-Tjahjadi H M
Br J Cancer. 1977 Mar;35(3):288-91. doi: 10.1038/bjc.1977.41.
Serum alpha-foetoprotein (AFP) and serum carcinoembryonic antigen (CEA) levels were measured, serially whenever possible, in 70 patients attending the Institute of Radiotherapy, Rotterdam, on account of testicular (65) or ovarian (4) germ cell tumours or, in one case, an endodermal sinus (yolk sac) tumour in the mediastinum. In 15 patients the disease was active; in the others it was in remission. Patients with active disease had raised serum AFP levels which correlated well with disease activity; no patient without evidence of active disease had raised serum AFP levels. None of the patients with active disease was found to have raised serum CEA levels. There was no correlation between serum AFP and CEA levels in patients with germ cell neoplasms, but good correlation between serum AFP levels and disease activity. Serum CEA levels did not correlate with disease activity, and serial determinations would therefore not be useful in monitoring progress in this group of diseases.
对鹿特丹放射治疗研究所的70例患者（其中65例为睾丸生殖细胞肿瘤，4例为卵巢生殖细胞肿瘤，1例为纵隔内胚窦瘤（卵黄囊瘤））尽可能连续地检测了血清甲胎蛋白（AFP）和血清癌胚抗原（CEA）水平。15例患者疾病处于活动期，其余患者病情缓解。疾病活动期患者的血清AFP水平升高，且与疾病活动情况密切相关；无疾病活动证据的患者血清AFP水平均未升高。疾病活动期患者均未发现血清CEA水平升高。生殖细胞肿瘤患者的血清AFP和CEA水平之间无相关性，但血清AFP水平与疾病活动情况相关性良好。血清CEA水平与疾病活动情况无关，因此连续检测对监测这类疾病的进展并无帮助。
