Laufer P, Fink J N, Bruns W T, Unger G F, Kalbfleisch J H, Greenberger P A, Patterson R
J Allergy Clin Immunol. 1984 Jan;73(1 Pt 1):44-8. doi: 10.1016/0091-6749(84)90482-2.
One hundred patients with CF were screened for ABPA. Forty-eight male patients and 52 female patients with age range of 2 to 34 yr (mean 14.2) were studied. Patients were evaluated for skin reactivity and serum precipitating antibodies to Af, predominant sputum organisms, total blood eosinophil levels, total serum IgE, and Af-specific IgE and IgG, as well as abnormalities of pulmonary function and chest x-ray films. Careful evaluation of all patients with CF demonstrated that 10% had features indicative of ABPA, which is another potentially destructive pulmonary disorder. Thus careful evaluation of patients with CF, especially those with asthma, may be rewarding in uncovering a disorder that may slow progression of CF when it is appropriately treated.
对100例囊性纤维化（CF）患者进行了变应性支气管肺曲霉菌病（ABPA）筛查。研究对象为48例男性和52例女性患者，年龄范围为2至34岁（平均14.2岁）。对患者进行了皮肤反应性、针对烟曲霉菌（Af）的血清沉淀抗体、主要痰液微生物、全血嗜酸性粒细胞水平、总血清免疫球蛋白E（IgE）以及Af特异性IgE和IgG的评估，同时还评估了肺功能和胸部X光片的异常情况。对所有CF患者的仔细评估表明，10%的患者具有提示ABPA的特征，ABPA是另一种具有潜在破坏性的肺部疾病。因此，对CF患者，尤其是患有哮喘的患者进行仔细评估，可能有助于发现一种在适当治疗时可减缓CF进展的疾病。
