Schønheyder H, Jensen T, Høiby N, Koch C
Institute of Medical Microbiology, University of Aarhus, Denmark.
Int Arch Allergy Appl Immunol. 1988;85(4):472-7. doi: 10.1159/000234554.
A 5.5-year survey revealed 9 patients with allergic bronchopulmonary aspergillosis (ABPA) and 1 patient with a highly probable diagnosis among 200 Danish patients with cystic fibrosis (CF). The incidence of ABPA was 0.9 (0.4-1.7, 95% confidence limits) per 100 patients per year. All the patients with definite or probable ABPA had serum antibodies to the Aspergillus fumigatus catalase antigen, and in 5 patients the appearance of catalase antibodies during the incipient phase of ABPA was documented. 29 patients without ABPA also had catalase antibodies, but in lower levels than ABPA patients (p = 0.006). The 6-month prevalence rate of A. fumigatus in sputum was 80 and 72% in the 2 groups, respectively. The finding of catalase antibodies in some CF patients without ABPA may indicate the occurrence of a symptom-poor form of pulmonary aspergillosis.
一项为期5.5年的调查显示，在200名丹麦囊性纤维化（CF）患者中，有9例患有变应性支气管肺曲霉病（ABPA），1例极有可能被诊断为此病。ABPA的发病率为每年每100例患者中有0.9例（0.4 - 1.7，95%置信区间）。所有确诊或可能患有ABPA的患者均有针对烟曲霉过氧化氢酶抗原的血清抗体，并且有5例患者记录了在ABPA初期过氧化氢酶抗体的出现情况。29例未患ABPA的患者也有过氧化氢酶抗体，但水平低于ABPA患者（p = 0.006）。两组患者痰液中烟曲霉的6个月患病率分别为80%和72%。在一些未患ABPA的CF患者中发现过氧化氢酶抗体可能表明存在一种症状较轻的肺曲霉病形式。
