Loranger A W
Arch Gen Psychiatry. 1984 Feb;41(2):157-61. doi: 10.1001/archpsyc.1984.01790130053007.
The age at onset of schizophrenia was determined in 100 male and 100 female patients who unequivocally met DSM-III criteria for the illness. Three different indexes of onset were used: first treatment, first hospitalization, and the immediate family's first awareness of psychotic symptoms and signs. The mean age at onset of the male patients was approximately five years earlier than that of the female patients according to all three criteria. About nine of ten male patients, compared with only two of three female patients, became schizophrenic before the age of 30 years. The onset of psychosis after the age of 35 years occurred in 17% of women and in only 2% of men. About 10% of women gave no evidence of psychosis until after the age of 40 years. The reason for the sex difference is not readily apparent, but it could be a valuable clue to some of the causes of schizophrenia.
在100名明确符合精神分裂症DSM-III诊断标准的男性患者和100名女性患者中确定了精神分裂症的起病年龄。使用了三种不同的起病指标：首次治疗、首次住院以及直系亲属首次意识到精神病症状和体征的时间。根据所有这三个标准，男性患者的平均起病年龄比女性患者早约5年。十分之九的男性患者在30岁之前患精神分裂症，而女性患者中只有三分之二在30岁之前患病。35岁之后出现精神病症状的情况在17%的女性中出现，而在男性中仅为2%。约10%的女性直到40岁之后才出现精神病症状。性别差异的原因并不明显，但这可能是精神分裂症某些病因的一个重要线索。
