Simpson R W, McGinty L, Simon L, Smith C A, Godzeski C W, Boyd R J
Science. 1984 Mar 30;223(4643):1425-8. doi: 10.1126/science.6701529.
A small virus resembling parvoviruses in its morphological and physicochemical properties was derived from synovial tissue of a patient with severe rheumatoid arthritis. This virus, designated RA-1, elicits a syndrome in neonatal mice that includes neurological disturbances, permanent crippling of limbs, dwarfism, alopecia, blepharitis, "masking," and a rigid curvature of the thoracic spine. Polyclonal antibodies against RA-1 display high virus neutralizing activity and in immunoassays detect reactive antigen in synovial cells from different rheumatoid arthritis patients but not persons with osteoarthritis. Putative parvoviruses isolated from several other rheumatoid arthritis patients are only weakly pathogenic for newborn mice but can generate RA-1 virus-specific antigens in tissues of these animals. It has not been established that RA-1 and existing parvoviruses of mammalian species are related.
一种在形态和物理化学性质上类似于细小病毒的小病毒，是从一名严重类风湿性关节炎患者的滑膜组织中分离出来的。这种病毒被命名为RA - 1，可在新生小鼠中引发一种综合征，包括神经功能紊乱、肢体永久性残废、侏儒症、脱发、睑缘炎、“面具样面容”以及胸椎僵硬弯曲。针对RA - 1的多克隆抗体具有很高的病毒中和活性，并且在免疫测定中能检测到来自不同类风湿性关节炎患者滑膜细胞中的反应性抗原，但在骨关节炎患者中未检测到。从其他几名类风湿性关节炎患者中分离出的假定细小病毒对新生小鼠的致病性较弱，但能在这些动物的组织中产生RA - 1病毒特异性抗原。目前尚未确定RA - 1与哺乳动物现有的细小病毒是否相关。
