Sohmer H, Pratt H, Kinarti R
Electroencephalogr Clin Neurophysiol. 1977 May;42(5):656-64. doi: 10.1016/0013-4694(77)90282-6.
In order to study the sources and pathways which are responsible for the frequency following response (FFR), records were made in control subjects and in patients with special types of lesion and response. It has already been shown that the FFR in normal subjects to tone bursts with single onset phases is made up of a short latency cochlear microphonic potential (CM) and a longer latency neural component (neural FFR). No neural FFR could be recorded in patients with upper brain-stem lesions (absence of click-evoked responses from the inferior colliculus along with clinical signs of such a lesion). Their FFR was exclusively a cochlear microphonic potential, thus demonstrating that the neural FFR with a latency of 6 msec is generated in the region of the inferior colliculus. Also in subjects with large post-auricular muscle (PAM) responses, the PAM can contribute to the FFR, with a latency of 10 msec. In patients with high-tone hearing loss due to acoustic trauma, no CM could be recorded while a neural FFR with a latency of 6 msec was present. This indicates that the CM recorded by this technique may be generated in the basal turn. It also demonstrates that the pathway of the neural FFR begins in the apical turn of the cochlea.
为了研究与频率跟随反应（FFR）相关的来源和途径，我们对正常受试者以及患有特殊类型病变和反应的患者进行了记录。已经表明，正常受试者对具有单个起始相位的短纯音爆发的FFR由短潜伏期的耳蜗微音器电位（CM）和较长潜伏期的神经成分（神经FFR）组成。在上脑干病变患者中无法记录到神经FFR（下丘没有点击诱发反应以及此类病变的临床体征）。他们的FFR完全是耳蜗微音器电位，从而证明潜伏期为6毫秒的神经FFR是在下丘区域产生的。同样，在耳后大肌（PAM）反应较大的受试者中，PAM可对FFR产生影响，潜伏期为10毫秒。在因声创伤导致高音听力损失的患者中，无法记录到CM，但存在潜伏期为6毫秒的神经FFR。这表明通过该技术记录的CM可能在耳蜗底部产生。这也表明神经FFR的途径始于耳蜗的顶部。
