AC-1370对吞噬细胞功能的作用机制。
Mechanism of action of AC-1370 on phagocyte functions.
作者信息
Ohnishi H, Inaba H, Mochizuki H, Kosuzume H
出版信息
Antimicrob Agents Chemother. 1984 Jan;25(1):88-92. doi: 10.1128/AAC.25.1.88.
The mechanism of action of a new semisynthetic cephalosporin AC-1370 on phagocyte functions was investigated. AC-1370 enhanced phagocytic functions of macrophages and neutrophils. AC-1370 bound to 27.4% of mouse peritoneal resident cells. Most of the AC-1370-binding cells were macrophages, and few neutrophils bound AC-1370. Culture supernatant of mouse macrophages cultured with AC-1370 significantly augmented phagocytic functions of mouse neutrophils. This activity of the culture supernatant of AC-1370-stimulated macrophages was abolished by digestion with trypsin but not by heat treatment at 56 degrees C for 30 min. The mechanism of the activation of phagocyte functions by AC-1370 is proposed as follows. First, AC-1370 binds to macrophages and causes their activation. Second, trypsin-sensitive and heat-stable soluble factor(s) is released from these macrophages. And finally, neutrophil functions are activated by the factor(s).
研究了一种新型半合成头孢菌素AC - 1370对吞噬细胞功能的作用机制。AC - 1370增强了巨噬细胞和中性粒细胞的吞噬功能。AC - 1370与27.4%的小鼠腹腔常驻细胞结合。大多数AC - 1370结合细胞是巨噬细胞，很少有中性粒细胞结合AC - 1370。用AC - 1370培养的小鼠巨噬细胞的培养上清液显著增强了小鼠中性粒细胞的吞噬功能。AC - 1370刺激的巨噬细胞培养上清液的这种活性可被胰蛋白酶消化消除，但在56℃加热30分钟不能消除。AC - 1370激活吞噬细胞功能的机制如下。首先，AC - 1370与巨噬细胞结合并使其激活。其次，这些巨噬细胞释放出对胰蛋白酶敏感且耐热的可溶性因子。最后，中性粒细胞功能被该因子激活。
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