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抗感染药物对多形核中性粒细胞的作用。

Effects of anti-infectious agents on polymorphonuclear neutrophils.

作者信息

Labro M T, el Benna J

机构信息

INSERM U. 294, Centre Hospitalier Universitaire X. Bichat, Paris, France.

出版信息

Eur J Clin Microbiol Infect Dis. 1991 Feb;10(2):124-31. doi: 10.1007/BF01964424.

DOI:10.1007/BF01964424
PMID:1864274
Abstract

Polymorphonuclear neutrophils play a crucial role in host defences against infectious diseases. New trends in anti-infectious therapy require knowledge of the possible interactions between the drugs and the natural defence system. This overview summarizes some of the in vitro data on the effects of anti-infectious agents on neutrophils. The relevance for the clinical situation is discussed.

摘要

多形核中性粒细胞在宿主抵御传染病的防御中起着关键作用。抗感染治疗的新趋势需要了解药物与天然防御系统之间可能的相互作用。本综述总结了一些关于抗感染药物对中性粒细胞作用的体外数据，并讨论了其与临床情况的相关性。

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1
Effects of anti-infectious agents on polymorphonuclear neutrophils.抗感染药物对多形核中性粒细胞的作用。
Eur J Clin Microbiol Infect Dis. 1991 Feb;10(2):124-31. doi: 10.1007/BF01964424.
2
Modulation of human polymorphonuclear neutrophil function by macrolides: preliminary data concerning dirithromycin.大环内酯类药物对人多形核中性粒细胞功能的调节作用：关于地红霉素的初步数据。
J Antimicrob Chemother. 1993 Mar;31 Suppl C:51-64. doi: 10.1093/jac/31.suppl_c.51.
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Antibiotics and host defence with special reference to phagocytosis by human polymorphonuclear leukocytes.抗生素与宿主防御，特别提及人类多形核白细胞的吞噬作用
J Antimicrob Chemother. 1985 Aug;16(2):135-41. doi: 10.1093/jac/16.2.135.
4
Effects of antimicrobial and antineoplastic drugs on the phagocytic and microbicidal function of the polymorphonuclear leukocyte.抗菌和抗肿瘤药物对多形核白细胞吞噬及杀菌功能的影响。
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Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes.甲砜霉素对人多形核白细胞抗化脓性链球菌主要功能的影响。
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Influence of midecamycin acetate, a new macrolide antibiotic, on bactericidal action of human polymorphonuclear leukocytes.新型大环内酯类抗生素麦迪霉素醋酸酯对人多形核白细胞杀菌作用的影响。
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Antibiotic-host defence interactions in vitro and in vivo.抗生素与宿主防御在体外和体内的相互作用。
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本文引用的文献

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Phagocyte strategy vs. microbial tactics.吞噬细胞策略与微生物战术
Rev Infect Dis. 1980 Sep-Oct;2(5):817-38. doi: 10.1093/clinids/2.5.817.
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Bacterial defence against antibiotics.
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Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studies.氨基糖苷类抗生素对溶酶体磷脂酶的抑制作用：体外比较研究。
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Effect of polymorphonuclear neutrophils on serum bactericidal activity against Streptococcus pneumoniae after amoxicillin administration.阿莫西林给药后多形核中性粒细胞对血清抗肺炎链球菌杀菌活性的影响。
Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):40-3. doi: 10.1007/BF01584362.
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Immunomodulating effects of antibiotics: literature review.抗生素的免疫调节作用：文献综述
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Effect of ciprofloxacin and other quinolones on granulocyte function assessed by flow cytometry.环丙沙星及其他喹诺酮类药物对通过流式细胞术评估的粒细胞功能的影响。
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Effect of cefodizime and ceftriaxone on phagocytic function in patients with severe infections.头孢地嗪和头孢曲松对重症感染患者吞噬功能的影响。
Antimicrob Agents Chemother. 1995 Mar;39(3):672-6. doi: 10.1128/AAC.39.3.672.
8
Subinhibitory concentrations of cefpodoxime alter membrane protein expression of Actinobacillus actinomycetemcomitans and enhance its susceptibility to killing by neutrophils.头孢泊肟的亚抑菌浓度可改变伴放线放线杆菌的膜蛋白表达，并增强其对中性粒细胞杀伤作用的敏感性。
Antimicrob Agents Chemother. 1995 Feb;39(2):406-12. doi: 10.1128/AAC.39.2.406.
9
Immunomodulation by antibacterial agents. Is it clinically relevant?抗菌药物的免疫调节作用。这在临床上有相关性吗？
Drugs. 1993 Mar;45(3):319-28. doi: 10.2165/00003495-199345030-00001.
10
Phagocytes, antibiotics and intracellular parasites: are the experimental data clinically relevant?吞噬细胞、抗生素与细胞内寄生虫：实验数据与临床相关吗？
Eur J Clin Microbiol Infect Dis. 1991 Feb;10(2):97-9. doi: 10.1007/BF01964419.
4
Effects of antimicrobial and antineoplastic drugs on the phagocytic and microbicidal function of the polymorphonuclear leukocyte.抗菌和抗肿瘤药物对多形核白细胞吞噬及杀菌功能的影响。
Rev Infect Dis. 1982 May-Jun;4(3):683-97. doi: 10.1093/clinids/4.3.683.
5
Potentiation of phagocytosis of pathogenic bacteria by exposure to low concentrations of antibiotics.
J Antimicrob Chemother. 1984 May;13(5):407-9. doi: 10.1093/jac/13.5.407.
6
Mechanism of action of AC-1370 on phagocyte functions.AC-1370对吞噬细胞功能的作用机制。
Antimicrob Agents Chemother. 1984 Jan;25(1):88-92. doi: 10.1128/AAC.25.1.88.
7
Effects of AC-1370, a new semisynthetic cephalosporin, on phagocyte functions.新型半合成头孢菌素AC-1370对吞噬细胞功能的影响。
Antimicrob Agents Chemother. 1983 Jun;23(6):874-80. doi: 10.1128/AAC.23.6.874.
8
Inactivation of netilmicin and amikacin by intact or disrupted leucocytes.完整或破损白细胞对奈替米星和阿米卡星的灭活作用。
J Antimicrob Chemother. 1984 Oct;14(4):435-8. doi: 10.1093/jac/14.4.435.
9
Inhibition of polymorphonuclear leukocyte functions by chlortetracycline.金霉素对多形核白细胞功能的抑制作用。
Biochem Pharmacol. 1984 Nov 15;33(22):3667-73. doi: 10.1016/0006-2952(84)90155-2.
10
The role of oxygen and its derivatives in microbial pathogenesis and host defense.氧气及其衍生物在微生物致病机制和宿主防御中的作用。
Annu Rev Microbiol. 1984;38:27-48. doi: 10.1146/annurev.mi.38.100184.000331.