Freal J E, Kraft G H, Coryell J K
Arch Phys Med Rehabil. 1984 Mar;65(3):135-8.
Symptomatic fatigue has not been investigated previously in a multiple sclerosis population. Potential subjects were the 78% of 656 individuals with multiple sclerosis who indicated in a previous study that they experienced symptomatic fatigue. Three hundred nine subjects (60%) returned a follow-up questionnaire on symptomatic fatigue. Ninety percent described fatigue as "tiredness or the need to rest," but 43% of them indicated that "sleepiness" was part of the symptomatology. In 48% fatigue made other MS symptoms worse. Fatigue tended to occur in the late afternoon and evening. It occurred almost daily for more than 66% of the subjects. In 47% of the subjects fatigue usually subsided within a few hours; in other subjects occurrences were of variable length (40%) or lasted between 6 and 24 hours (8%). Ninety percent said that fatigue was worse at warmer environmental temperatures. Fatigue was worse for 83% after "vigorous exercise" and for 64% after "moderate exercise" although 15% reported that moderate exercise helped to reduce fatigue. Meditation, some drugs, and cooling with water reduced fatigue in a majority of the small proportion of the population trying these techniques. A planned daily schedule of activity and rest seemed to be a partially effective response to symptomatic fatigue for the majority of subjects studied.
此前尚未在多发性硬化症患者群体中对症状性疲劳进行过研究。潜在研究对象为656名多发性硬化症患者中的78%，这些患者在之前的一项研究中表示他们经历过症状性疲劳。309名受试者（60%）返回了关于症状性疲劳的随访问卷。90%的人将疲劳描述为“疲倦或需要休息”，但其中43%的人表示“嗜睡”是症状之一。48%的患者中，疲劳会使其他多发性硬化症症状加重。疲劳往往在下午晚些时候和晚上出现。超过66%的受试者几乎每天都会出现疲劳。47%的受试者疲劳通常会在几个小时内缓解；其他受试者疲劳出现的时长不一（40%），或持续6至24小时（8%）。90%的人表示在环境温度较高时疲劳会加重。83%的人在“剧烈运动”后疲劳加重，64%的人在“适度运动”后疲劳加重，不过15%的人报告称适度运动有助于减轻疲劳。对于尝试这些方法的少数人群中的大多数而言，冥想、某些药物以及用水降温可减轻疲劳。对于大多数研究对象来说，有计划的日常活动和休息安排似乎是应对症状性疲劳的一种部分有效的方法。
