Husslein P, Sinzinger H
Br J Obstet Gynaecol. 1984 Mar;91(3):228-31. doi: 10.1111/j.1471-0528.1984.tb04757.x.
The concentration of 13,14-dihydro-15-keto-PGE2 (PGEM) was measured by radioimmunoassay in pregnant women in the third trimester, in women at term but not in labour and during labour of spontaneous onset. The plasma concentration of PGEM in pregnant women was elevated above that in a non-pregnant control group. Before the onset of labour no increase of PGEM concentration could be identified. Women in labour had higher PGEM plasma concentrations than before the onset of labour, although there was no progressive increase. Immediately after delivery PGEM levels reached a maximum, which decreased significantly to pre-labour values within 30 min. Artificial rupture of the membranes had no influence on plasma PGEM levels. It is concluded that labour is associated with an increased synthesis of PGE2 and that PGE2 may be involved in the mechanism of placental separation. The rapid disappearance of high PGEM levels after labour confirms that PGE2 is probably synthesized mainly in the fetal compartment.
采用放射免疫分析法测定了晚期妊娠孕妇、足月未临产孕妇及自然发动分娩孕妇血浆中13,14-二氢-15-酮-前列腺素E2（PGEM）的浓度。孕妇血浆中PGEM浓度高于非孕对照组。临产前未发现PGEM浓度升高。临产孕妇血浆中PGEM浓度高于临产前，尽管并非呈进行性升高。分娩后即刻PGEM水平达到最高值，30分钟内显著降至临产前水平。人工破膜对血浆PGEM水平无影响。研究得出结论，分娩与PGE2合成增加有关，且PGE2可能参与胎盘剥离机制。分娩后PGEM高水平迅速消失，证实PGE2可能主要在胎儿部分合成。
