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处理细胞毒性药物时使用的防护手套的效率。

The efficiency of protective gloves used in the handling of cytotoxic drugs.

作者信息

Slevin M L, Ang L M, Johnston A, Turner P

出版信息

Cancer Chemother Pharmacol. 1984;12(3):151-3. doi: 10.1007/BF00256536.

DOI:10.1007/BF00256536
PMID:6705132
Abstract

A range of clinical and industrial gloves have been evaluated to determine their ability to exclude penetration by cytotoxic drugs. Radiolabelled cyclophosphamide, methotrexate, daunomycin, cytosine arabinoside, and vincristine sulphate were studied in an equilibrium dialysis system in which the glove material was used as the dialysis membrane. The thicker gloves were the most effective, but very little drug crossed any of the gloves tested under laboratory conditions. Further studies to evaluate gloves in conditions of clinical use are now needed.

摘要

已经对一系列临床和工业用手套进行了评估,以确定它们阻止细胞毒性药物渗透的能力。在一个平衡透析系统中研究了放射性标记的环磷酰胺、甲氨蝶呤、柔红霉素、阿糖胞苷和硫酸长春新碱,其中手套材料用作透析膜。较厚的手套效果最佳,但在实验室条件下,测试的任何手套都只有极少的药物透过。现在需要进一步研究以评估临床使用条件下的手套。

相似文献

1
The efficiency of protective gloves used in the handling of cytotoxic drugs.处理细胞毒性药物时使用的防护手套的效率。
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2
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引用本文的文献

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Drugs hazardous to healthcare workers. Evaluation of methods for monitoring occupational exposure to cytostatic drugs.对医护人员有害的药物。监测细胞毒性药物职业暴露方法的评估。
Drug Saf. 1999 Apr;20(4):347-59. doi: 10.2165/00002018-199920040-00004.
2
Biological monitoring of cyclophosphamide and ifosfamide in urine of hospital personnel occupationally exposed to cytostatic drugs.对职业接触细胞毒性药物的医院工作人员尿液中环磷酰胺和异环磷酰胺的生物监测。
Occup Environ Med. 1994 Apr;51(4):229-33. doi: 10.1136/oem.51.4.229.
3
Biological and environmental monitoring of occupational exposure of pharmaceutical plant workers to methotrexate.

本文引用的文献

1
Handling of injectable antineoplastic agents.注射用抗肿瘤药物的处理
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Risk of handling injectable antineoplastic agents.注射用抗肿瘤药物的处理风险。
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Protective capacity of gloves used for handling of nitrogen mustard.用于处理氮芥的手套的防护能力。
制药厂工人职业接触甲氨蝶呤的生物与环境监测
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Mutagenicity in urine of nurses handling cytostatic drugs.接触细胞毒性药物的护士尿液中的致突变性。
Lancet. 1979 Jun 9;1(8128):1250-1. doi: 10.1016/s0140-6736(79)91939-1.