DiPalma J A, Brady C E, Stewart D L, Karlin D A, McKinney M K, Clement D J, Coleman T W, Pierson W P
Gastroenterology. 1984 May;86(5 Pt 1):856-60.
Colonoscopy cleansing regimens were evaluated in 197 patients randomized in two study phases to one of four methods: group 1 (64 patients), 3-day clear liquid diet; group 2 (40 patients), 3-day minimum-residue diet; group 3 (44 patients), 1-day minimum-residue diet; group 4 (49 patients), Golytely. Groups 1-3 also received laxatives and enemas before colonoscopy. Physician assessment by endoscopists unaware of the method of colon cleansing favored group 4 (p less than 0.001), with good to excellent preparations achieved in 69% of group 1, 80% of groups 2 and 3, and 92% of group 4. Group 4 patients also experienced less abdominal distress (p less than 0.01). Breath hydrogen and methane levels were measured in groups 3 and 4 both before and after preparation. The decrease in pre- to postprep levels of hydrogen and methane were not significantly different between the groups and postprep gas concentrations were below combustible levels in both groups. There were no clinically significant differences between the four groups for any of the other measured hematologic or biochemical parameters. It is concluded that Golytely is a safe, effective method of colon cleansing, well tolerated by patients.
对197例患者的结肠镜检查肠道清洁方案进行了评估，这些患者在两个研究阶段被随机分为四种方法之一：第1组（64例患者），3天清流食；第2组（40例患者），3天低渣饮食；第3组（44例患者），1天低渣饮食；第4组（49例患者），服用复方聚乙二醇电解质散。第1 - 3组在结肠镜检查前还接受了泻药和灌肠。由不了解肠道清洁方法的内镜医师进行的医师评估显示第4组更受青睐（p<0.001），第1组69%、第2组和第3组80%、第4组92%的患者肠道准备达到良好至优秀。第４组患者的腹部不适也较少（p<0.01）。对第3组和第4组在准备前后测量了呼气氢气和甲烷水平。两组之间准备前后氢气和甲烷水平的下降没有显著差异，且两组准备后的气体浓度均低于可燃水平。在任何其他测量的血液学或生化参数方面，四组之间没有临床显著差异。结论是复方聚乙二醇电解质散是一种安全、有效的肠道清洁方法，患者耐受性良好。
