Hangartner P J, Münch R, Meier J, Ammann R, Bühler H
Department of Medicine, University Hospital, Zurich, Switzerland.
Endoscopy. 1989 Nov;21(6):272-5. doi: 10.1055/s-2007-1012967.
In a prospective randomized clinical trial, three colon cleansing methods for colonoscopy were compared with regard to a) side effects, b) patient acceptance, c) residual liquid and stool during colonoscopy, and d) quality of the examination. The patients were randomly assigned to one of the following three groups for colon preparation: Group 1 (n = 100) 4 liters of Golytely, group 2 (n = 102) 2 liters of Golytely combined with Cascara-Salax, and group 3 (n = 98) X-Prep (a Senna preparation) combined with an enema. X-Prep (group 3) caused significantly more abdominal cramps than 4 liters of Golytely (group 1) or 2 liters of Golytely with Cascara-Salax (group 2) (p less than 0.001). Vomiting was most frequent in group 1 (p less than 0.05 vs. group 3). The patients therefore preferred X-Prep to 4 liters of Golytely (p less than 0.01). The cleanest colon was obtained with 4 liters of Golytely, while 2 liters of Golytely with Cascara-Salax was least efficacious. The quality of the examination was equal in groups 1 and 3, and clearly better than in group 2 (p less than 0.01). We thus conclude that while 4 liters of Golytely and X-Prep plus enema have equivalent cleansing efficacy for colonoscopy, patients judged X-Prep to be less unpleasant.
在一项前瞻性随机临床试验中，对三种用于结肠镜检查的结肠清洁方法在以下方面进行了比较：a）副作用，b）患者接受度，c）结肠镜检查期间的残留液体和粪便，以及d）检查质量。患者被随机分配到以下三组之一进行结肠准备：第1组（n = 100），使用4升聚乙二醇电解质散；第2组（n = 102），使用2升聚乙二醇电解质散联合番泻叶-沙拉克斯；第3组（n = 98），使用X-Prep（一种番泻叶制剂）联合灌肠。与4升聚乙二醇电解质散（第1组）或2升聚乙二醇电解质散联合番泻叶-沙拉克斯（第2组）相比，X-Prep（第3组）引起的腹部绞痛明显更多（p < 0.001）。呕吐在第1组中最为常见（与第3组相比，p < 0.05）。因此，患者更喜欢X-Prep而非4升聚乙二醇电解质散（p < 0.01）。使用4升聚乙二醇电解质散可获得最清洁的结肠，而2升聚乙二醇电解质散联合番泻叶-沙拉克斯的效果最差。第1组和第3组的检查质量相当，且明显优于第2组（p < 0.01）。我们因此得出结论，虽然4升聚乙二醇电解质散和X-Prep加灌肠在结肠镜检查中的清洁效果相当，但患者认为X-Prep的不适感较小。
