Holden B A, Sweeney D F, Sanderson G
Invest Ophthalmol Vis Sci. 1984 Apr;25(4):476-80.
One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension of 74 mmHg). There was considerable individual variation both in the corneal swelling response with each of the various oxygen concentrations and in the atmospheric oxygen concentration required to avoid edema: one subject required 7.5%, four subjects required 10.1%, and three subjects required 21.4% oxygen concentration. The results of this study suggest that the cornea requires higher levels of atmospheric oxygen than previously considered necessary for normal function.
八名受试者每人的一只眼睛分别暴露于氧气浓度为1.0%、2.5%、4.9%、7.5%、10.1%和21.4%（氧分压范围为8至158毫米汞柱）的气体中8小时。整个组避免角膜水肿所需的角膜前氧浓度为10.1%（氧张力为74毫米汞柱）。在不同氧浓度下的角膜肿胀反应以及避免水肿所需的大气氧浓度方面，个体差异都很大：一名受试者需要7.5%的氧浓度，四名受试者需要10.1%，三名受试者需要21.4%的氧浓度。这项研究的结果表明，角膜所需的大气氧水平比以前认为的正常功能所需水平更高。
