Waggener T B, Brusil P J, Kronauer R E, Gabel R A, Inbar G F
J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):576-81. doi: 10.1152/jappl.1984.56.3.576.
Respiration was monitored with magnetometers in 12 healthy supine young adults at sea level and in an altitude chamber at simulated high altitudes of 8,000, 9,000, 11,000, and 14,000 ft. Periodic breathing that was strong enough to include apnea at the time of minimum ventilation was seen in all subjects at high altitude. Cycle time of periodic breathing ranged from 12 to 34 s. On average across the population the incidence of periodic breathing increased with altitude. Cycle time of the periodic pattern increased as strength of the pattern increased. After normalizing to a standard pattern strength, cycle time decreased as altitude increased. The study included two series of experiments, the second occurring 3 wk after the first and involving seven of the same subjects. The standard cycle time at 14,000 ft for each subject in the second series was the same as in the first series to within, on the average, 6%. Each subject studied at 11,000 ft in both series reproduced his cycle time to within, on the average, 9%. The variation of standard cycle time for a given subject is less than the variation across the population, indicating characteristic cycle times for some individuals (one-way analysis of variance, P less than 0.025).
在海平面以及模拟海拔8000英尺、9000英尺、11000英尺和14000英尺的高海拔舱内，使用磁力计对12名健康仰卧的年轻成年人的呼吸进行了监测。在高海拔地区，所有受试者均出现了强度足以在最小通气时出现呼吸暂停的周期性呼吸。周期性呼吸的周期时间为12至34秒。在整个人口中，周期性呼吸的发生率平均随海拔升高而增加。周期性模式的周期时间随着模式强度的增加而增加。在将模式强度标准化后，周期时间随着海拔升高而缩短。该研究包括两个系列的实验，第二个实验在第一个实验3周后进行，涉及7名相同的受试者。第二个系列中，每个受试者在14000英尺处的标准周期时间与第一个系列中的平均相差不超过6%。在两个系列中，在11000英尺处接受研究的每个受试者的周期时间平均重现率在9%以内。给定受试者的标准周期时间变化小于整个人口中的变化，这表明某些个体具有特征性的周期时间（单因素方差分析，P<0.025）。
