Magnussen H, Reuss G
Klin Wochenschr. 1984 Feb 15;62(4):168-74. doi: 10.1007/BF01731639.
The bronchoconstrictor response to cold air breathing during exercise shows a wide interindividual variation in asthmatic patients. We investigated whether the protective effect of a single, inhaled dose of 0.2 mg fenoterol powder is dependent on the severity of airways obstruction, following placebo pretreatment of an inhalative thermal burden precisely matched in terms of respiratory heat exchange. In ten asthmatic patients 0.2 mg fenoterol powder or placebo were administered via an inhalator in a single blind and random order fashion on separate days. Lung function was measured before and 30 min after treatment (baseline value) and 3, 10, 15 and 30 min after an inhalative provocation consisting of cold air breathing during exercise. After placebo the maximal increase of airway resistance compared to the baseline value ranged from 682% to 50% (means +/- SD: 344.1 +/- 312.2) whereas fenoterol shifted the corresponding data to 58% and -23.0% (means +/- SD: 13.4 +/- 29.2). The protective effect of fenoterol did not depend on the reactivity of the airways to the stimulus applied. The results indicate that the inhalative pretreatment with 0.2 mg fenoterol powder is sufficient to block exercise-induced asthma even in those patients whose airways are highly sensitive to respiratory heat loss.
哮喘患者在运动期间对冷空气呼吸的支气管收缩反应存在很大的个体差异。我们研究了在呼吸热交换方面精确匹配的吸入性热负荷进行安慰剂预处理后，单次吸入0.2毫克非诺特罗粉的保护作用是否取决于气道阻塞的严重程度。在10名哮喘患者中，在不同日期以单盲随机顺序通过吸入器给予0.2毫克非诺特罗粉或安慰剂。在治疗前和治疗后30分钟（基线值）以及在运动期间进行冷空气呼吸的吸入激发后3、10、15和30分钟测量肺功能。给予安慰剂后，与基线值相比气道阻力的最大增加范围为682%至50%（平均值±标准差：344.1±312.2），而非诺特罗使相应数据变为58%和-23.0%（平均值±标准差：13.4±29.2）。非诺特罗的保护作用不取决于气道对所施加刺激的反应性。结果表明，即使在气道对呼吸热损失高度敏感的患者中，吸入0.2毫克非诺特罗粉进行预处理也足以预防运动诱发的哮喘。
