Hilton A M, Hasleton P S, Bradlow A, Leahy B C, Cooper K M, Moore M
Thorax. 1984 Mar;39(3):185-91. doi: 10.1136/thx.39.3.185.
Four patients with severe bronchiectasis (chronic bronchial suppuration) are described who developed cutaneous lesions associated with exacerbations of their respiratory disease. The skin abnormalities consisted of purpuric lesions in three patients and an erythematous vasculitis in one. Circulating immune complexes were present in all patients and in three skin biopsy specimens showed deposition of C3, IgG, and IgA in dermal blood vessels. Haemophilus influenzae had been isolated from the sputum of all four patients and in two patients was present at the time the cutaneous lesions appeared. It is suggested that local immune complex deposition was responsible for the skin lesions which occurred during acute exacerbations of bronchiectasis.
本文描述了4例严重支气管扩张（慢性支气管化脓症）患者，他们在呼吸道疾病加重时出现了皮肤病变。皮肤异常表现为3例患者出现紫癜性病变，1例患者出现红斑性血管炎。所有患者均存在循环免疫复合物，3例患者的皮肤活检标本显示真皮血管中有C3、IgG和IgA沉积。所有4例患者的痰液中均分离出流感嗜血杆菌，其中2例患者在皮肤病变出现时该菌仍存在。提示局部免疫复合物沉积是支气管扩张急性加重期出现皮肤病变的原因。
