Pedersen P A, Rung Weeke E
Allergy. 1984 Apr;39(3):165-70. doi: 10.1111/j.1398-9995.1984.tb02620.x.
The seasonal variation of consultations on account of asthma and allergic rhinitis, and the relationship with air concentrations of pollen, spores, and lead, cadmium, dust, soot and sulfur dioxide was investigated in Danish general practice during a 1-year period 1977-78. A population of about 500,000 was studied. Among about 3000 asthmatics there were less consultations during spring than the rest of the year, but the seasonal variation of consultations with symptoms was rather small. The highest rate of consultations was in week 24, which is close to the peak of the grass pollen period. No relationship was found between asthma symptoms and concentrations of pollution indicators. Among about 5000 patients with allergic rhinitis the rate of consultations with symptoms increased at the start of the tree pollen season, still more at the start of the birch pollen season, and was very high during weeks 21-26 in the grass pollen season. Two thirds of all consultations for symptomatic allergic rhinitis took place within 10 weeks (Nos. 18-27). During the grass pollen season there was a relative preponderance of young patients, while during the birch pollen season older patients dominated. No connection was seen between rhinitis symptoms and pollution indicators. The different seasonal variation of asthma and allergic rhinitis indicates that the two patient categories differ as regards symptom-provoking factors. Allergic rhinitis is mainly precipitated by grass and birch pollen. The precipitating factors of asthma were not disclosed in this study, with the exception perhaps of some influence from pollen, and - among 0-4-year-old children - respiratory infections.
1977 - 1978年期间,在丹麦的全科医疗中,对因哮喘和过敏性鼻炎进行的会诊的季节性变化,以及与花粉、孢子、铅、镉、灰尘、烟尘和二氧化硫的空气浓度之间的关系进行了调查。研究了约50万人口。在约3000名哮喘患者中,春季的会诊次数少于一年中的其他时间,但有症状会诊的季节性变化相当小。会诊率最高的是在第24周,这接近草花粉期的高峰期。未发现哮喘症状与污染指标浓度之间存在关联。在约5000名过敏性鼻炎患者中,有症状会诊的比率在树花粉季节开始时增加,在桦树花粉季节开始时增加得更多,并且在草花粉季节的第21 - 26周非常高。所有有症状的过敏性鼻炎会诊中有三分之二发生在10周内(第18 - 27周)。在草花粉季节,年轻患者相对较多,而在桦树花粉季节,老年患者占主导。未发现鼻炎症状与污染指标之间存在关联。哮喘和过敏性鼻炎不同的季节性变化表明,这两类患者在症状诱发因素方面存在差异。过敏性鼻炎主要由草和桦树花粉引发。本研究未揭示哮喘的诱发因素,可能除了花粉的一些影响,以及在0 - 4岁儿童中,呼吸道感染的影响。