Alspaugh M A, Talal N, Tan E M
Arthritis Rheum. 1976 Mar-Apr;19(2):216-22. doi: 10.1002/art.1780190214.
Autoantibodies in Sjögren's syndrome (SS) were identified by their precipitin reactions with tissue antigens in immunodiffusion. The source of antigens was a sonicated extract of human lymphoid cells (WiI2) grown in tissue culture. Three distinct precipitin systems were identified and referred to as precipitins SS-A and SS-B, and rheumatoid arthritis precipitin. These studies show that precipitins SS-A and SS-B are present in high frequency in sera of patients with SS without associated rheuamtoid arthritis (RA) and are absent or present in low frequency in many other connective tissue diseases. On the other hand patients with SS who also had clinical features compatible with RA (SS-RA) did not have precipitins SS-A and SS-B but had rheumatoid arthritis precipitin (RAP). The latter precipitin was also present in RA patients in a similar order of frequency as in SS-RA. All three precipitin systems were shown to be reactions betweeen immunoglobulins and cellular antigens. The origin of SS-A and SS-B antigens was demonstrated by immunofluorescence to be primarily from the nucleus but the origin of RAP in the cell has not been established.
干燥综合征（SS）中的自身抗体是通过其在免疫扩散中与组织抗原的沉淀反应来鉴定的。抗原来源是在组织培养中生长的人淋巴细胞（WiI2）的超声提取物。鉴定出三种不同的沉淀系统，分别称为沉淀素SS - A和SS - B以及类风湿性关节炎沉淀素。这些研究表明，沉淀素SS - A和SS - B在无相关类风湿性关节炎（RA）的SS患者血清中高频存在，而在许多其他结缔组织疾病中不存在或低频存在。另一方面，具有与RA相符临床特征的SS患者（SS - RA）没有沉淀素SS - A和SS - B，但有类风湿性关节炎沉淀素（RAP）。后一种沉淀素在RA患者中的出现频率与在SS - RA中相似。所有三种沉淀系统均显示为免疫球蛋白与细胞抗原之间的反应。免疫荧光显示SS - A和SS - B抗原主要来自细胞核，但RAP在细胞中的起源尚未确定。
