Kirland J, Lye M, Goddard C, Vargas E, Davies I
Clin Endocrinol (Oxf). 1984 Apr;20(4):451-6. doi: 10.1111/j.1365-2265.1984.tb03441.x.
Plasma arginine vasopressin was assessed by radioimmunoassay in dehydrated elderly patients and healthy young and elderly control subjects. The elderly control subjects' AVP levels were higher than the young control subjects (Kruskal-Wallis rank sums z = 3.29; P less than 0.001). Despite similar plasma osmolalities, after correction for the osmotic contribution of urea, the patients' AVP levels were higher than the elderly controls (z = 4.16; P less than 0.001) and were in the range reported to evoke a maximal antidiuretic response. It is concluded that the dehydration which often accompanies acute illness in the elderly is not primarily a consequence of inadequate AVP release.
采用放射免疫分析法对脱水老年患者以及健康青年和老年对照者的血浆精氨酸加压素进行了评估。老年对照者的精氨酸加压素水平高于青年对照者（克鲁斯卡尔-沃利斯秩和检验z = 3.29；P<0.001）。尽管血浆渗透压相似，但在校正尿素的渗透作用后，患者的精氨酸加压素水平高于老年对照者（z = 4.16；P<0.001），且处于据报道可引起最大抗利尿反应的范围内。得出的结论是，老年人急性疾病常伴随的脱水并非主要是精氨酸加压素释放不足的结果。
