新型合成前列腺素MDL 646对大鼠胃黏膜乙醇损伤的保护作用
Protection of rat gastric mucosa against ethanol injury by the new synthetic prostaglandin MDL 646.
作者信息
Pallavicini G, Bardoni A, Profumo A, Castellani A A, Schiatti P, Glässer A
出版信息
Experientia. 1984 Apr 15;40(4):371-2. doi: 10.1007/BF01952558.
PMID:6714368
Abstract
Oral administration to fasted rats of absolute ethanol produces extensive necrotic lesions of gastric mucosa as well as a massive leakage of proteins and mucus glycoproteins into gastric lumen. When the new synthetic prostaglandin MDL 646, belonging to the PGE1 series, is administered intragastrically (2 or 10 micrograms/kg) 30 min before ethanol administration, a significant protection of rat gastric mucosa against alcohol injury is observed.
摘要
给禁食的大鼠口服无水乙醇会导致胃黏膜出现广泛的坏死性病变，同时蛋白质和黏液糖蛋白大量渗漏到胃腔中。当在给予乙醇前30分钟经胃内给予属于PGE1系列的新型合成前列腺素MDL 646（2或10微克/千克）时，可观察到大鼠胃黏膜对酒精损伤有显著的保护作用。
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