Morse H C, Pumphrey J G, Potter M, Asofsky R
J Immunol. 1976 Aug;117(2):541-7.
Primary ascites from 778 consecutive plasmacytomas of BALB/c and other mouse strains were tested by immunoelectrophoresis for the presence of paraproteins belonging to different immunoglobulin classes. gammaA was produced by 338 tumors: gamma Gs (gamma 1, gamma 2a, gamma 2b, or gamma 3) by 163 tumors; and gamma M by seven tumors. Free kappa- or lambda-typed light chains were produced by 14 tumors, and no detectable paraprotein was produced by 202 tumors. Two or more paraproteins were detected in the primary ascites of 54 plasmacytomas. Evidence suggests that in most cases, the multiple paraproteins are produced by simultaneously occurring, independent plasma cell tumors. However, two tumors, SAMM 368 and TEPC 609, produced two paraproteins for over 30 generations in transplantation. This finding implies that single clones of plasma cells have the capacity to produce more than one class of immunoglobulin.
对来自BALB/c及其他小鼠品系的778例连续性浆细胞瘤的原发性腹水进行免疫电泳检测，以确定是否存在属于不同免疫球蛋白类别的副蛋白。338个肿瘤产生γA；163个肿瘤产生γGs（γ1、γ2a、γ2b或γ3）；7个肿瘤产生γM。14个肿瘤产生游离的κ型或λ型轻链，202个肿瘤未产生可检测到的副蛋白。在54例浆细胞瘤的原发性腹水中检测到两种或更多种副蛋白。有证据表明，在大多数情况下，多种副蛋白是由同时发生的独立浆细胞瘤产生的。然而，在移植过程中，有两个肿瘤，即SAMM 368和TEPC 609，连续30多代产生了两种副蛋白。这一发现意味着浆细胞的单个克隆有能力产生不止一类免疫球蛋白。
