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New inhibitors of platelet aggregation. 5'-Phosphate, 5'-phosphorothioate, and 5'-O-sulfamoyl derivatives of 2-substituted adenosine analogues.

作者信息

Gough G R, Nobbs D M, Middleton J C, Penglis-Caredes F, Maguire M H

出版信息

J Med Chem. 1978 Jun;21(6):520-5. doi: 10.1021/jm00204a004.

DOI:10.1021/jm00204a004
PMID:671448
Abstract
摘要

相似文献

1
New inhibitors of platelet aggregation. 5'-Phosphate, 5'-phosphorothioate, and 5'-O-sulfamoyl derivatives of 2-substituted adenosine analogues.血小板聚集的新型抑制剂。2-取代腺苷类似物的5'-磷酸酯、5'-硫代磷酸酯和5'-O-氨磺酰衍生物。
J Med Chem. 1978 Jun;21(6):520-5. doi: 10.1021/jm00204a004.
2
Effects of adenosine analogs and adenine nucleotides on adenosine 5'-diphosphate-induced rat platelet aggregation.腺苷类似物和腺嘌呤核苷酸对二磷酸腺苷诱导的大鼠血小板聚集的影响。
Biochem Pharmacol. 1980 Jun 15;29(12):1799-805. doi: 10.1016/0006-2952(80)90142-2.
3
Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation.
Bioorg Med Chem Lett. 2008 Mar 15;18(6):2167-71. doi: 10.1016/j.bmcl.2008.01.038. Epub 2008 Jan 13.
4
Adenine nucleotides as tools in platelet studies.腺嘌呤核苷酸作为血小板研究的工具。
Proc West Pharmacol Soc. 1981;24:381-4.
5
Effects of photolysable 2-azido analogues of adenosine, AMP and ADP on human platelets.
Proc R Soc Lond B Biol Sci. 1977 Jul 20;197(1129):515-20. doi: 10.1098/rspb.1977.0084.
6
Platelet aggregation inhibitors. IX. Chemical transformation of adenosine into 2-thioadenosine derivatives.血小板聚集抑制剂。IX。腺苷向2-硫代腺苷衍生物的化学转化。
Chem Pharm Bull (Tokyo). 1977 Aug;25(8):1959-69. doi: 10.1248/cpb.25.1959.
7
Inhibition of ADP-induced platelet aggregation by adenosine tetraphosphate.四磷酸腺苷对二磷酸腺苷诱导的血小板聚集的抑制作用。
Thromb Haemost. 1976 Nov 30;36(2):388-91.
8
Effects of D- and L- enantiomers of adenosine, AMP and ADP and their 2-chloro- and 2-azido- analogues on human platelets.腺苷、AMP和ADP的D型和L型对映体及其2-氯代和2-叠氮基类似物对人血小板的作用。
Proc R Soc Lond B Biol Sci. 1979 Nov 30;206(1163):139-44. doi: 10.1098/rspb.1979.0097.
9
Specific but noncompetitive inhibition by 2-alkylthio analogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate.5'-二磷酸腺苷诱导的人血小板聚集受到5'-单磷酸腺苷和5'-三磷酸腺苷的2-烷硫基类似物的特异性而非竞争性抑制。
Br J Pharmacol. 1982 Feb;75(2):397-400. doi: 10.1111/j.1476-5381.1982.tb08800.x.
10
Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase.霉酚酸腺嘌呤二核苷酸的新型亚甲基膦酸膦酸酯类似物。肌苷单磷酸脱氢酶的抑制作用。
J Med Chem. 2006 Aug 10;49(16):5018-22. doi: 10.1021/jm060479r.

引用本文的文献

1
Isolation of 5'--sulfamyladenosine and related 3'--β-glucosylated adenosines from the nucleocidin producer .从杀核苷菌素产生菌中分离5'-磺酰胺腺苷及相关的3'-β-葡萄糖基化腺苷。
RSC Adv. 2021 Jan 28;11(10):5291-5294. doi: 10.1039/d1ra00235j.
2
5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation.5'-N-乙基羧酰胺腺苷：一种有效的人类血小板聚集抑制剂。
Br J Pharmacol. 1981 Mar;72(3):443-7. doi: 10.1111/j.1476-5381.1981.tb10995.x.
3
Specific but noncompetitive inhibition by 2-alkylthio analogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate.
5'-二磷酸腺苷诱导的人血小板聚集受到5'-单磷酸腺苷和5'-三磷酸腺苷的2-烷硫基类似物的特异性而非竞争性抑制。
Br J Pharmacol. 1982 Feb;75(2):397-400. doi: 10.1111/j.1476-5381.1982.tb08800.x.
4
Acetal phosphatidic acids: novel platelet aggregating agents.缩醛磷脂酸：新型血小板聚集剂。
Br J Pharmacol. 1983 May;79(1):157-66. doi: 10.1111/j.1476-5381.1983.tb10508.x.
5
Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid.棕榈醛缩醛磷脂酸激活的人血小板中的花生四烯酸代谢、5-羟色胺释放及聚集
Br J Pharmacol. 1984 May;82(1):61-72. doi: 10.1111/j.1476-5381.1984.tb16442.x.
6
Adenosine 5-diphosphate antagonists and human platelets: no evidence that aggregation and inhibition of stimulated adenylate cyclase are mediated by different receptors.腺苷5-二磷酸拮抗剂与人类血小板：无证据表明聚集和刺激型腺苷酸环化酶的抑制作用由不同受体介导。
Br J Pharmacol. 1982 May;76(1):221-7. doi: 10.1111/j.1476-5381.1982.tb09210.x.