Hu T S, Datiles M, Kinoshita J H
Invest Ophthalmol Vis Sci. 1983 May;24(5):640-4.
Sorbinil, a potent aldose reductase inhibitor, can effectively block the progression of a galactose cataract even though the cataractous process is well underway. The prevention of dulcitol accumulation by Sorbinil is just as effective in reversing the cataract as the removal of galactose from the diet. The progression and reversal of the cataract were followed by ophthalmoscopy and histology. The results also further support the concept that in galactosemia the cataract is not caused by the toxic effects of galactose per se but by the consequence of the aldose reductase reaction.
索比尼尔是一种有效的醛糖还原酶抑制剂，即使白内障过程已经充分发展，它也能有效阻止半乳糖性白内障的进展。索比尼尔阻止山梨醇积累在逆转白内障方面与从饮食中去除半乳糖一样有效。通过检眼镜检查和组织学观察白内障的进展和逆转情况。这些结果还进一步支持了这样一种观点，即在半乳糖血症中，白内障不是由半乳糖本身的毒性作用引起的，而是由醛糖还原酶反应的结果所致。
