Morgenstern H, Gellert G A, Walter S D, Ostfeld A M, Siegel B S
J Chronic Dis. 1984;37(4):273-82. doi: 10.1016/0021-9681(84)90135-8.
A retrospective follow-up study was conducted to assess the impact of a psychosocial support program on survival with breast cancer. One-hundred and two nonparticipants were individually matched to 34 participants on several prognostic factors, and both groups were followed from date of cancer diagnosis (1971-1980) until December, 1981. Preliminary findings suggest a strong beneficial effect of the program on survival, which is statistically significant. However, this observed effect is due largely to a selection bias caused by the failure to match on the duration of the lag period between cancer diagnosis and program entry. Correcting for this bias in the analysis results in a small, nonsignificant program effect. We are not able to rule out a possible effect, however, because of the relative lack of statistical power and because of a modest, though nonsignificant benefit observed for women who entered the program shortly after diagnosis. Furthermore, the program might have other beneficial effects on the quality of life.
开展了一项回顾性随访研究，以评估一项社会心理支持项目对乳腺癌患者生存情况的影响。根据若干预后因素，将102名未参与者与34名参与者进行个体匹配，两组均从癌症诊断日期（1971年至1980年）开始随访，直至1981年12月。初步研究结果表明，该项目对生存具有显著的有益影响，具有统计学意义。然而，这一观察到的效果很大程度上是由于在癌症诊断与项目参与之间的滞后期持续时间方面未能进行匹配而导致的选择偏倚。在分析中校正这一偏倚后，项目效果变得微小且无统计学意义。不过，由于相对缺乏统计效能，且诊断后不久就参与项目的女性虽有适度但无统计学意义的获益，因此我们无法排除可能存在的效果。此外，该项目可能对生活质量有其他有益影响。
