Greenblatt D J, Allen M D
JAMA. 1978 Aug 11;240(6):542-4.
Among 26,294 hospitalized medical patients monitored by the Boston Collaborative Drug Surveillance Program, 46% received at least one intramuscular (IM) injection. Drugs for which IM injection was the route of administration in more than 80% of all exposures included penicillin G procaine, mercurial diuretics, cyanocobalamin, streptomycin sulfate, colistimethate sodium, meperidine hydrochloride, cephaloridine, scopolamine hydrobromide, kanamycin sulfate, and iron dextran injection. Local complications of IM injection were reported in a total of only 48 patients (0.4% of all IM recipients). Local complications were most commonly associated with IM injection of cephalothin sodium. Clinically important local complications are uncommonly associated with IM injections in general. However, certain drugs, eg, cephalothin, produce injection-site complications with relatively high frequency; the clinical role of IM injection of such drugs should be reevaluated.
在波士顿药物监测协作计划监测的26294名住院内科患者中，46%的患者至少接受过一次肌肉注射。在所有暴露中，肌肉注射给药途径占比超过80%的药物包括普鲁卡因青霉素G、汞利尿剂、氰钴胺、硫酸链霉素、多粘菌素甲磺酸钠、盐酸哌替啶、头孢菌素、氢溴酸东莨菪碱、硫酸卡那霉素和右旋糖酐铁注射液。总共只有48名患者（占所有接受肌肉注射患者的0.4%）报告了肌肉注射的局部并发症。局部并发症最常与头孢噻吩钠的肌肉注射有关。一般来说，临床上重要的局部并发症很少与肌肉注射有关。然而，某些药物，如头孢噻吩，会相对频繁地产生注射部位并发症；此类药物肌肉注射的临床作用应重新评估。
