[Age-related characteristics of the manifestation of the diabetogenic factor in the blood of animals maintained on natural and atherogenic diets].

The diabetogenic activity was studied in the blood plasma of rats of different age, kept on the natural and atherogenic diet. The relationship between the diabetogenic factor presence and functional condition of the anticoagulating system was investigated. The plasma of rat donors, examined for the presence of diabetogenic factor in their blood, was transfused to normal rat recipients (three transfusions of 1 ml per 200 g body weight daily). The activity of diabetogenic factor was determined according to a hyperglycemia degree in the blood of normal rat recipients. It was found that the blood plasma of old animals, kept on the natural diet, contains heparin-neutralizing diabetogenic factor. In middle-aged animals, kept on the atherogenic diet for a long time, the arising of more active diabetogenic factor in the blood is accelerated. The degree of the diabetogenic effect development in animal donors is directly dependent on their age and the function depression extent of the second anticoagulative system.