Kudriashov B A, Ul'ianov A M, Bazaz'ian G G, Pytel' Iu A
Probl Endokrinol (Mosk). 1984 Mar-Apr;30(2):65-70.
The diabetogenic activity was studied in the blood plasma of rats of different age, kept on the natural and atherogenic diet. The relationship between the diabetogenic factor presence and functional condition of the anticoagulating system was investigated. The plasma of rat donors, examined for the presence of diabetogenic factor in their blood, was transfused to normal rat recipients (three transfusions of 1 ml per 200 g body weight daily). The activity of diabetogenic factor was determined according to a hyperglycemia degree in the blood of normal rat recipients. It was found that the blood plasma of old animals, kept on the natural diet, contains heparin-neutralizing diabetogenic factor. In middle-aged animals, kept on the atherogenic diet for a long time, the arising of more active diabetogenic factor in the blood is accelerated. The degree of the diabetogenic effect development in animal donors is directly dependent on their age and the function depression extent of the second anticoagulative system.
研究了不同年龄、分别采用天然饮食和致动脉粥样化饮食喂养的大鼠血浆中的致糖尿病活性。研究了致糖尿病因子的存在与抗凝系统功能状态之间的关系。对大鼠供血者的血液进行检测，以确定其中是否存在致糖尿病因子，然后将其血浆输注给正常的大鼠受体（每天按每200克体重1毫升的剂量进行三次输注）。根据正常大鼠受体血液中的高血糖程度来确定致糖尿病因子的活性。结果发现，采用天然饮食喂养的老年动物的血浆中含有可中和肝素的致糖尿病因子。长期采用致动脉粥样化饮食喂养的中年动物，其血液中更活跃的致糖尿病因子的产生会加速。动物供血者中致糖尿病效应的发展程度直接取决于其年龄和第二抗凝系统的功能抑制程度。
