Thompson H J, Chasteen N D, Meeker L D
Carcinogenesis. 1984 Jun;5(6):849-51. doi: 10.1093/carcin/5.6.849.
The induction of murine mammary carcinogenesis by 1-methyl-1-nitrosourea was blocked by the feeding of a purified diet formulation supplemented with 25 p.p.m. vanadium as vanadyl(IV) sulfate during the post initiation stages of the neoplastic process. Treatment with vanadyl(IV) sulfate reduced both cancer incidence and the average number of cancers per rat and prolonged the median cancer-free time without inhibiting the overall growth of the animals. Vanadyl(IV) sulfate appears to be an effective non-toxic agent for the chemoprevention of experimental breast cancer in the rat.
在肿瘤形成过程的起始后阶段，通过喂食添加了25 ppm硫酸氧钒形式钒的纯化饮食配方，可阻断1-甲基-1-亚硝基脲诱导的小鼠乳腺癌发生。硫酸氧钒处理降低了癌症发病率和每只大鼠的平均癌症数量，并延长了无癌中位时间，同时不抑制动物的整体生长。硫酸氧钒似乎是一种有效的无毒药物，可用于大鼠实验性乳腺癌的化学预防。
