The role of immune complexes for the origin of liver lesions.

Immunocomplexes (IC) are frequently determined in cases of viral hepatitis B. especially in sera where HBsAg has been detected by RIA method. In HAV infection IC have not been detected, as well as in normal controls. After the addition of immunoglobulin anti HBs the concentration of IC in serum significantly rises. In HA infection and in healthy controls such an elevation does not appear. The diagnostic and differential diagnostic value of IC determination in viral hepatitis has been discussed as well as some problems of the therapeutic use of immunoglobulins.