正常受试者食管中呃逆的刺激及部位特异性诱导
Stimulus and site specific induction of hiccups in the oesophagus of normal subjects.
作者信息
Fass R, Higa L, Kodner A, Mayer E A
机构信息
Department of Medicine, UCLA, USA.
出版信息
Gut. 1997 Nov;41(5):590-3. doi: 10.1136/gut.41.5.590.
BACKGROUND
Hiccups that are induced by a large meal have been suggested to result from gastric overdistension. The role of the oesophagus in precipitating hiccups has never been defined.
AIMS
To determine the involvement of oesophageal mechanoreceptors in the hiccup reflex.
METHODS
Ten normal healthy subjects were prospectively evaluated at a university affiliated hospital. Controlled inflation of a polyethylene bag in the proximal and distal oesophagus was carried out using slow ramp and rapid phasic distensions, by an electronic distension device.
RESULTS
Hiccups were induced in four subjects only during rapid phasic distensions and only in the proximal oesophagus. The mean (SEM) minimal volume threshold for the hiccup reflex was 32.5 (4.8) ml, which was above the perception threshold. Hiccups appeared during inflation and resolved after deflation.
CONCLUSIONS
Sudden rapid stretch of the mechanoreceptors in the proximal oesophagus can trigger the hiccup reflex in normal subjects. Only rapid distensions above a determined volume threshold will predictably induce hiccups in a given subject. This mechanism may play a role in the physiological induction of hiccups.
背景
大量进食引发的打嗝被认为是由胃过度扩张所致。食管在引发打嗝中所起的作用尚未明确。
目的
确定食管机械感受器在打嗝反射中的作用。
方法
在一家大学附属医院对10名正常健康受试者进行前瞻性评估。使用电子扩张装置，通过缓慢斜坡式和快速相位扩张，对食管近端和远端的聚乙烯袋进行控制性充气。
结果
仅在快速相位扩张期间且仅在食管近端，4名受试者诱发了打嗝。打嗝反射的平均（标准误）最小容积阈值为32.5（4.8）毫升，高于感知阈值。打嗝在充气时出现，放气后缓解。
结论
食管近端机械感受器的突然快速拉伸可触发正常受试者的打嗝反射。仅高于特定容积阈值的快速扩张可在给定受试者中可预测地诱发打嗝。这一机制可能在打嗝的生理诱发中起作用。
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