Reiss G R, Lee D A, Topper J E, Brubaker R F
Invest Ophthalmol Vis Sci. 1984 Jun;25(6):776-8.
The rate of aqueous humor flow of 19 normal subjects was measured by a fluorescein clearance technique during the day, during sleep (at night) and during sleep deprivation (at night). Subjects engaged in routine activities during the daytime measurements and slept in comfortable quarters during the nighttime measurement. They remained awake and active during the sleep deprivation study. The nomographic method of Coakes and Brubaker , a method in which the subject is not disturbed at all during the critical 5-hr period, was used to calculate flow. Flow was lower during sleep in all but one subject. The range of nighttime flow suppression was 8% to 68% in all of the other subjects with a mean suppression of 45% +/- 20%. Aqueous flow was lower at night even when the subjects were awake but was lowest during sleep at night. The reduction of aqueous flow during sleep is comparable with the suppression that can be achieved with carbonic anhydrase inhibitors or beta adrenergic blockers.
采用荧光素清除技术，在白天、睡眠期间（夜间）以及睡眠剥夺期间（夜间）对19名正常受试者的房水生成率进行了测量。白天测量时，受试者进行日常活动；夜间测量时，受试者在舒适的环境中睡眠。在睡眠剥夺研究期间，受试者保持清醒并处于活动状态。采用Coakes和Brubaker的列线图法计算房水生成率，该方法在关键的5小时期间完全不会干扰受试者。除一名受试者外，所有受试者睡眠期间的房水生成率均较低。其他所有受试者夜间房水生成率的抑制范围为8%至68%，平均抑制率为45%±20%。即使受试者处于清醒状态，夜间房水生成率也较低，但在夜间睡眠期间最低。睡眠期间房水生成率的降低程度与使用碳酸酐酶抑制剂或β肾上腺素能阻滞剂所能达到的抑制程度相当。
