Itoh Yoshinori, Nakamoto Kenji, Horiguchi Hiroshi, Ogawa Shumpei, Noro Takahiko, Sato Makoto, Nakano Tadashi, Tsuneoka Hiroshi, Yasuda Noriko
Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan.
Department of Ophthalmology, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
J Ophthalmol. 2017;2017:4398494. doi: 10.1155/2017/4398494. Epub 2017 May 3.
To evaluate 24-hour intraocular pressure (IOP) variation in patients with primary open-angle glaucoma (POAG) treated with triple eye drops. The IOP was measured in 74 eyes in 74 POAG patients (seated) on triple therapy (PG analogue, -blocker, carbonic anhydrase inhibitor) at about every 3 hours. The peak IOP was 13.5 ± 3.1 at 1:00, and the trough IOP was at 12.6 ± 2.4 mmHg at 7:00. The IOP at 7:00 was significantly lower than that at 10:00, 1:00, and 3:00 ( < 0.05). Based on the time of the peak IOP, we classified the patients into two groups: diurnal (28 eyes) and nocturnal types (37 eyes). There was significant difference at the spherical equivalent between diurnal and nocturnal types ( = 0.014). To assess the influence of reflective error, we conducted subanalysis for two groups: high myopic (26 eyes, ≤-6D) and low/nonmyopic (24 eyes, ≥-2D) groups. In the low/nonmyopia group, the IOP was significantly higher at 1:00 and 3:00 than at 13:00, 16:00, and 7: 00 ( < 0.05). The mean of IOP elevated outside of clinic hour in the POAG patients on triple therapy. The low/nonmyopia patient should be carefully treated because the IOP of the patients at night elevated significantly.
评估三联眼药水治疗原发性开角型青光眼（POAG）患者24小时眼压（IOP）的变化。对74例接受三联疗法（前列腺素类似物、β受体阻滞剂、碳酸酐酶抑制剂）治疗的POAG患者的74只眼（坐位）大约每3小时测量一次眼压。眼压峰值在1:00时为13.5±3.1，谷值眼压在7:00时为12.6±2.4mmHg。7:00时的眼压显著低于10:00、1:00和3:00时的眼压（P<0.05）。根据眼压峰值时间，将患者分为两组：日间型（28只眼）和夜间型（37只眼）。日间型和夜间型在等效球镜度上存在显著差异（P = 0.014）。为评估屈光不正的影响，我们对两组进行了亚分析：高度近视组（26只眼，≤-6D）和低度/非近视组（24只眼，≥-2D）。在低度/非近视组中，1:00和3:00时的眼压显著高于13:00、16:00和7:00时的眼压（P<0.05）。三联疗法治疗的POAG患者在门诊时间外眼压均值升高。低度/非近视患者应谨慎治疗，因为其夜间眼压显著升高。
