Cramer D W, Welch W R, Hutchison G B, Willett W, Scully R E
Obstet Gynecol. 1984 Jun;63(6):833-8.
Food and beverage frequency questionnaires were administered to 215 white women with epithelial ovarian cancer and to 215 control women matched by age, race, and residence. Women with ovarian cancer favored foods higher in animal fats and consumed significantly greater amounts of animal fat and significantly less vegetable fat compared with control subjects. Adjusted for potential confounding due to differences between case and control subjects in weight and parity, there was a significant trend for increasing risk for ovarian cancer with increasing animal fat consumption. No major differences were noted between patients and control subjects in coffee, alcohol, and tobacco use. Dietary factors may partially explain variation in the international incidence of this disease and suggest a new pathway for its etiology.
对215名患有上皮性卵巢癌的白人女性以及215名年龄、种族和居住地相匹配的对照女性进行了饮食频率问卷调查。与对照对象相比，卵巢癌女性更喜欢动物脂肪含量较高的食物，摄入的动物脂肪量显著更多，而植物脂肪量显著更少。对病例组和对照组在体重和生育状况方面的差异导致的潜在混杂因素进行调整后，随着动物脂肪摄入量的增加，患卵巢癌的风险呈显著上升趋势。在咖啡、酒精和烟草使用方面，患者与对照对象之间未发现重大差异。饮食因素可能部分解释了这种疾病国际发病率的差异，并为其病因学提出了一条新途径。
