Mommers M, Schouten L J, Goldbohm R A, van den Brandt P A
Department of Epidemiology, NUTRIM, Maastricht University, PO Box 616, Maastricht 6200 MD, The Netherlands.
Br J Cancer. 2006 Jan 16;94(1):165-70. doi: 10.1038/sj.bjc.6602890.
Ovary cancer risk in relation to consumption of dairy products was investigated using a self-administered questionnaire on dietary habits and other risk factors for cancer, which was completed in 1986 by 62 573 postmenopausal women participating in the Netherlands Cohort Study. Follow-up for cancer was implemented by annual record linkage with the Netherlands Cancer Registry and a nationwide pathology registry. After 11.3 years of follow-up, data of 252 incident epithelial ovarian cancer cases and 2216 subcohort members were available for analysis. No association was seen between consumption of milk, yoghurt, cheese or fermented dairy products and ovarian cancer risk. The multivariable adjusted relative risk of epithelial ovarian cancer for women in the highest compared to the lowest quintile of intake of lactose or dairy fat was 0.93 (95% confidence interval (CI)=0.60-1.45; P(trend)=0.32) and 1.53 (95% CI=1.00-2.36; P(trend)=0.11), respectively. Lactose or dairy fat intakes were not associated with serous ovarian cancer risk. Our results do not support an association between consumption of dairy products or lactose intake and ovarian cancer.
通过一份关于饮食习惯和其他癌症风险因素的自填式问卷，对乳制品消费与卵巢癌风险之间的关系进行了调查。该问卷于1986年由62573名参与荷兰队列研究的绝经后女性完成。通过与荷兰癌症登记处和全国病理登记处进行年度记录链接来实施癌症随访。经过11.3年的随访，有252例上皮性卵巢癌病例和2216名亚队列成员的数据可供分析。未发现牛奶、酸奶、奶酪或发酵乳制品的消费与卵巢癌风险之间存在关联。乳糖或乳制品脂肪摄入量最高五分位数的女性与最低五分位数的女性相比，上皮性卵巢癌的多变量调整相对风险分别为0.93（95%置信区间（CI）=0.60-1.45；P趋势=0.32）和1.53（95%CI=1.00-2.36；P趋势=0.11）。乳糖或乳制品脂肪摄入量与浆液性卵巢癌风险无关。我们的结果不支持乳制品消费或乳糖摄入量与卵巢癌之间存在关联。
