锌与Z型DNA
Zinc Z-DNA.
作者信息
Fazakerley G V
出版信息
Nucleic Acids Res. 1984 Apr 25;12(8):3643-8. doi: 10.1093/nar/12.8.3643.
Abstract
Circular dichroism spectra of poly(dG-dC) in the presence of some zinc complexes exhibit the characteristic inversion associated with the formation of a left handed helix. The transition of B to Z DNA is cooperative and slow. The concentration of zinc complex at the mid point of the transition is strongly dependent upon the nature of the ligand bound to zinc. The most efficient species is one with a tetradentate amine for which the mid point is observed at a zinc:nucleotide ratio of 1:24. 31P spectra of one of these complexes confirm the presence of a left handed helix.
摘要
在某些锌配合物存在下，聚（dG-dC）的圆二色光谱呈现出与左手螺旋形成相关的特征性反转。B型DNA向Z型DNA的转变是协同且缓慢的。转变中点处锌配合物的浓度强烈依赖于与锌结合的配体的性质。最有效的物种是一种具有四齿胺的物种，其在锌与核苷酸比例为1:24时观察到中点。这些配合物之一的³¹P光谱证实了左手螺旋的存在。
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