Carpentier P, Franco A
J Mal Vasc. 1984;9(1):23-8.
Nailfold capillary microscopy is a simple and noninvasive screening test for the etiological diagnosis of Raynaud's phenomenon: --dilating capillary dystrophia, with its large capillary loops (megacapillaries), it is a very specific sign of connective tissue disorders, especially systemic sclerosis; --meshed or branched-tree shaped capillaries are neocapillaries, the meaning of which is very often a dermal vasculitis (S. L. E., rheumatoid arthritis, paraneoplastic Raynaud's phenomenon, or even chilblains); --when numerous abnormal capillary loops and hemorrhages are seen without any special pattern, the diagnosis of idiopathic Raynaud's disease is very unlikely and an extensive biological investigation is needed; --nailfold capillaries look like normal in idiopathic Raynaud's disease and, in this case, only a sharp physical examination and a few biological tests are required. Conjunctival angioscopy is a useful complementary test in some cases when nailfold capillaroscopy is unreliable. Capillary video microscopy is an interesting method for further investigations about the physiopathology of Raynaud's phenomenon.
——扩张性毛细血管营养不良，伴有大的毛细血管袢（巨型毛细血管），是结缔组织疾病尤其是系统性硬化症的非常特异的体征；——网状或树枝状毛细血管是新生毛细血管，其意义通常是皮肤血管炎（系统性红斑狼疮、类风湿关节炎、副肿瘤性雷诺现象，甚至冻疮）；——当见到大量异常毛细血管袢和出血且无任何特殊形态时，原发性雷诺病的诊断极不可能，需要进行广泛的生物学检查；——原发性雷诺病中甲襞毛细血管看起来正常，在这种情况下，仅需进行仔细的体格检查和一些生物学检查。在某些甲襞毛细血管镜检查不可靠的情况下，结膜血管镜检查是一种有用的补充检查。毛细血管视频显微镜检查是进一步研究雷诺现象病理生理学的一种有趣方法。
