维生素E治疗溶血性尿毒症综合征。
Vitamin E treatment of haemolytic uraemic syndrome.
作者信息
Powell H R, McCredie D A, Taylor C M, Burke J R, Walker R G
出版信息
Arch Dis Child. 1984 May;59(5):401-4. doi: 10.1136/adc.59.5.401.
Because low plasma vitamin E concentrations have been reported in patients with haemolytic uraemic syndrome and there is accumulating evidence of lipid peroxidation in this disease, treatment with the antioxidant vitamin E was undertaken in 16 consecutive children with the syndrome. Twelve children had features at presentation suggesting a poor prognosis for recovery but despite this all 16 patients survived and are well three months later. Fifteen children now have normal values for serum creatinine, blood pressure, and urinalysis for protein but one has slight renal impairment. Although this is not a report of a controlled trial, it seems that patients treated with vitamin E have fared considerably better than our previously treated patients with haemolytic uraemic syndrome, even in the presence of early, adverse prognostic features. We suggest that vitamin E alters the natural history of the disease, and in view of the absence of any observed side effects further experience with this treatment is being sought.
因为据报道，溶血性尿毒症综合征患者的血浆维生素E浓度较低，而且有越来越多的证据表明该疾病存在脂质过氧化现象，所以我们对16例连续性溶血性尿毒症综合征患儿采用抗氧化剂维生素E进行治疗。12例患儿在就诊时具有提示恢复预后不良的特征，但尽管如此，所有16例患者均存活，且3个月后情况良好。现在，15例患儿的血清肌酐、血压和尿蛋白分析结果均正常，但有1例存在轻度肾功能损害。尽管这不是一项对照试验的报告，但似乎接受维生素E治疗的患者比我们之前治疗的溶血性尿毒症综合征患者情况要好得多，即使存在早期不良预后特征也是如此。我们认为维生素E改变了该疾病的自然病程，鉴于未观察到任何副作用，正在寻求更多关于这种治疗方法的经验。
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