散发性溶血性尿毒症综合征中前列环素生成的抑制剂。
Inhibitor of prostacyclin production in sporadic haemolytic uraemic syndrome.
作者信息
Levin M, Elkon K B, Nokes T J, Buckle A M, Dillon M J, Hardisty R M, Barratt T M
出版信息
Arch Dis Child. 1983 Sep;58(9):703-8. doi: 10.1136/adc.58.9.703.
Abstract
Prostacyclin (PGI2) production was diminished when rat aortic rings were incubated with plasma from 5 of 6 patients with the sporadic form of haemolytic uraemic syndrome but was normal in the presence of plasma from 7 patients with the epidemic form of haemolytic uraemic syndrome or from patients with other renal diseases. The reduced PGI2 production was caused by an unstable inhibitor, extractable into polar lipid solvents, in sporadic haemolytic uraemic plasma. These results suggest that there may be at least 2 different pathogenetic mechanisms in epidemic and sporadic haemolytic uraemic syndrome and that the reduced PGI2 production observed in the sporadic type is due to an inhibitor of PGI2 production rather than a deficiency of stimulating factors.
摘要
当将大鼠主动脉环与6例散发性溶血性尿毒症综合征患者中5例的血浆一起孵育时，前列环素（PGI2）的生成减少，但在7例流行性溶血性尿毒症综合征患者或其他肾脏疾病患者的血浆存在下，PGI2生成正常。散发性溶血性尿毒症血浆中PGI2生成减少是由一种不稳定的抑制剂引起的，该抑制剂可提取到极性脂质溶剂中。这些结果表明，流行性和散发性溶血性尿毒症综合征可能至少有2种不同的发病机制，并且在散发性类型中观察到的PGI2生成减少是由于PGI2生成抑制剂而非刺激因子缺乏所致。
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