乳腺癌：原发肿瘤大小与转移扩散概率之间的关系
Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination.
作者信息
Koscielny S, Tubiana M, Lê M G, Valleron A J, Mouriesse H, Contesso G, Sarrazin D
出版信息
Br J Cancer. 1984 Jun;49(6):709-15. doi: 10.1038/bjc.1984.112.
Abstract
The relationship between the size of the primary tumour upon initial treatment and the incidence of distant metastasis during the course of the disease was investigated using data from 2648 breast cancers treated at the Institut Gustave Roussy between 1954 and 1972. This analysis suggests the existence for each tumour of a critical volume (threshold) at which the first remote metastasis is initiated. The correlation between the size of the primary tumour and the probability of metastatic dissemination was assessed as well as the influence on this correlation of two prognostic indicators: histological grade and number of involved lymph nodes. It was found that the threshold volume is strongly correlated with the number of involved lymph nodes and the histological grading.
摘要
利用1954年至1972年间在古斯塔夫·鲁西研究所接受治疗的2648例乳腺癌数据，研究了初始治疗时原发肿瘤大小与疾病过程中远处转移发生率之间的关系。该分析表明，每种肿瘤都存在一个临界体积（阈值），在这个体积时首次发生远处转移。评估了原发肿瘤大小与转移扩散概率之间的相关性，以及两个预后指标（组织学分级和受累淋巴结数量）对这种相关性的影响。结果发现，临界体积与受累淋巴结数量和组织学分级密切相关。
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本文引用的文献
1
Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.乳腺癌的组织学分级与预后；对1409例病例的研究，其中359例已随访15年。
Br J Cancer. 1957 Sep;11(3):359-77. doi: 10.1038/bjc.1957.43.
2
Observations on growth rates of human tumors.关于人类肿瘤生长速率的观察
Am J Roentgenol Radium Ther Nucl Med. 1956 Nov;76(5):988-1000.
3
Kinetic parameters and the course of the disease in breast cancer.乳腺癌的动力学参数与疾病进程
Cancer. 1981 Mar 1;47(5):937-43. doi: 10.1002/1097-0142(19810301)47:5<937::aid-cncr2820470520>3.0.co;2-6.
4
Ten- to fourteen-year effect of screening on breast cancer mortality.筛查对乳腺癌死亡率的10至14年影响。
J Natl Cancer Inst. 1982 Aug;69(2):349-55.
5
L.H. Gray Medal lecture: cell kinetics and radiation oncology.L.H. 格雷奖章讲座：细胞动力学与放射肿瘤学
Int J Radiat Oncol Biol Phys. 1982 Sep;8(9):1471-89. doi: 10.1016/0360-3016(82)90607-1.
6
Factors influencing short and long term survival of breast cancer patients.影响乳腺癌患者短期和长期生存的因素。
Surg Gynecol Obstet. 1966 Jun;122(6):1311-6.
7
[Age of metastatic adenopathies in breast cancer].[乳腺癌转移性淋巴结病的年龄]
Ann Anat Pathol (Paris). 1968 Oct-Dec;13(4):449-59.
8
Cancer of the breast: size of neoplasm and prognosis.乳腺癌：肿瘤大小与预后
Cancer. 1969 Nov;24(5):1071-80. doi: 10.1002/1097-0142(196911)24:5<1071::aid-cncr2820240533>3.0.co;2-h.
9
Relation between the pathological nature and the growth rate of human tumors.人类肿瘤的病理性质与生长速率之间的关系。
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10
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Bull Cancer. 1975 Oct-Dec;62(4):341-58.
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