Koscielny S, Tubiana M, Lê M G, Valleron A J, Mouriesse H, Contesso G, Sarrazin D
Br J Cancer. 1984 Jun;49(6):709-15. doi: 10.1038/bjc.1984.112.
The relationship between the size of the primary tumour upon initial treatment and the incidence of distant metastasis during the course of the disease was investigated using data from 2648 breast cancers treated at the Institut Gustave Roussy between 1954 and 1972. This analysis suggests the existence for each tumour of a critical volume (threshold) at which the first remote metastasis is initiated. The correlation between the size of the primary tumour and the probability of metastatic dissemination was assessed as well as the influence on this correlation of two prognostic indicators: histological grade and number of involved lymph nodes. It was found that the threshold volume is strongly correlated with the number of involved lymph nodes and the histological grading.
利用1954年至1972年间在古斯塔夫·鲁西研究所接受治疗的2648例乳腺癌数据，研究了初始治疗时原发肿瘤大小与疾病过程中远处转移发生率之间的关系。该分析表明，每种肿瘤都存在一个临界体积（阈值），在这个体积时首次发生远处转移。评估了原发肿瘤大小与转移扩散概率之间的相关性，以及两个预后指标（组织学分级和受累淋巴结数量）对这种相关性的影响。结果发现，临界体积与受累淋巴结数量和组织学分级密切相关。
