Pasternak J F, Groothuis D R
Brain Res. 1984 May 14;299(2):281-8. doi: 10.1016/0006-8993(84)90709-1.
Regional cerebral blood flow (RCBF) and local cerebral glucose utilization (LCGU) were studied in normal, awake newborn beagle puppies using quantitative autoradiography. A highly significant linear relationship between RCBF and LCGU was present for all brain structures. Special attention was directed to the subependymal germinal matrix (GM), the site of origin of periventricular hemorrhage in the premature human. A consistent variability in both RCBF and LCGU was found within GM. Both RCBF and LCGU were higher in rostral than posterior GM, and in peripheral than internal GM. The close coupling between RCBF and LCGU within GM suggests that GM blood flow is influenced by local energy needs. The quantitative relationship between RCBF and LCGU was similar within GM to that in cerebral white and gray matter, suggesting that the puppy GM predominantly utilizes glucose as fuel for energy production.
利用定量放射自显影技术，对正常、清醒的新生比格幼犬的局部脑血流量（RCBF）和局部脑葡萄糖利用率（LCGU）进行了研究。所有脑结构的RCBF和LCGU之间均存在高度显著的线性关系。特别关注了室管膜下生发基质（GM），这是早产儿脑室周围出血的起源部位。在GM内发现RCBF和LCGU均存在一致的变异性。GM内的头侧部分比后侧部分的RCBF和LCGU更高，外周部分比内部部分的更高。GM内RCBF和LCGU之间的紧密耦合表明，GM的血流受局部能量需求的影响。GM内RCBF和LCGU之间的定量关系与脑白质和灰质中的相似，这表明幼犬的GM主要利用葡萄糖作为能量产生的燃料。
