[患球虫病雏鸡肝脏中RNA生物合成的变化]

[Changes in RNA biosynthesis in the liver of chicks with coccidiosis].

作者信息

Aver'ianov A V, Zerov Iu P, Khovanskikh A E

出版信息

Parazitologiia. 1978 May-Jun;12(3):263-7.

Abstract

The RNA fraction and the intensity of their turnover in chick liver during experimental coccidiosis was studied. A marked (about 60%) increase of intensity of mRNA turnover with no changes in its amount was found. It was shown that pre-rRNA biosynthesis was significantly enhanced and, due to it, the amount of both pre-rRNA and mature 18S rRNA was increased while the level of 28S rRNA was unchanged. The relations between the observed changes of RNA biosynthesis and protein biosynthesis in liver in coccidiosis as well as the role of these changes in pathological process studied are discussed.

摘要

研究了实验性球虫病期间鸡肝脏中RNA组分及其周转强度。发现mRNA周转强度显著增加（约60%），但其数量没有变化。结果表明，前体rRNA生物合成显著增强，因此前体rRNA和成熟18S rRNA的数量均增加，而28S rRNA水平不变。讨论了球虫病时肝脏中观察到的RNA生物合成变化与蛋白质生物合成之间的关系，以及这些变化在研究的病理过程中的作用。

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