尿金属硫蛋白作为镉体内负荷及镉诱导肾毒性的指标。
Urinary metallothionein as an indicator of cadmium body burden and of cadmium-induced nephrotoxicity.
作者信息
Shaikh Z A, Tohyama C
出版信息
Environ Health Perspect. 1984 Mar;54:171-4. doi: 10.1289/ehp.8454171.
Abstract
There is a need to identify specific biological indicator(s) of cadmium exposure so that the renal damage can be prevented. Towards this end, we have examined the usefulness of urinary metallothionein as an indicator of cadmium body burden. It is found that, in both animals and humans, urinary metallothionein level is related to the hepatic and renal cadmium burdens. Significant correlations are also found between the urinary metallothionein and urinary cadmium and beta 2-microglobulin. Furthermore, it is noted that cadmium-exposed individuals with renal dysfunction excrete significantly more metallothionein than those with normal renal function. Thus it appears that there is merit to include metallothionein among the clinical parameters monitored in cadmium-exposed individuals. More tests are needed to define a critical concentration of metallothionein in urine which is related to the onset of renal dysfunction.
摘要
有必要确定镉暴露的特定生物学指标，以便预防肾脏损伤。为此，我们研究了尿金属硫蛋白作为镉体内负荷指标的实用性。结果发现，在动物和人类中，尿金属硫蛋白水平与肝脏和肾脏的镉负荷相关。尿金属硫蛋白与尿镉和β2-微球蛋白之间也存在显著相关性。此外，值得注意的是，肾功能不全的镉暴露个体比肾功能正常的个体排泄的金属硫蛋白明显更多。因此，在镉暴露个体监测的临床参数中纳入金属硫蛋白似乎是有价值的。需要更多测试来确定与肾功能不全发病相关的尿金属硫蛋白临界浓度。
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本文引用的文献
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