Nara Y, Kihara M, Nabika T, Mano M, Horie R, Yamori Y
Hypertension. 1984 May-Jun;6(3):339-43. doi: 10.1161/01.hyp.6.3.339.
Platelet aggregation induced by 5 microM adenosine 5'-diphosphate (ADP) was significantly higher in men with a family history of essential hypertension than in men without such a history when they were fed a low fat-cholesterol diet with low salt. Platelet aggregation activity was remarkably increased in both groups when the diet was changed from low salt into high salt. Platelet aggregation activity was higher in the group with a positive family history of hypertension on the low fat-cholesterol plus high salt diet than in the group without a family history under the same conditions. The activity was slightly increased in both groups when fed a high fat-cholesterol diet with low salt. There was no significant difference in the platelet aggregation between the two groups. The activity was significantly increased in both groups on the high fat-cholesterol diet after the diet was changed from low salt to high salt. Under both the low and high fat-cholesterol diets, the mean blood pressure was significantly elevated in response to excessive salt intake in the group with a family history of essential hypertension, but it was not elevated in the group without such a family history.
在摄入低脂 - 胆固醇低盐饮食时，有原发性高血压家族史的男性，其由5微摩尔腺苷5'-二磷酸（ADP）诱导的血小板聚集显著高于无此家族史的男性。当饮食从低盐改为高盐时，两组的血小板聚集活性均显著增加。在低脂 - 胆固醇加高盐饮食下，有高血压家族史阳性的组的血小板聚集活性高于相同条件下无家族史的组。当摄入低脂 - 胆固醇低盐饮食时，两组的活性均略有增加。两组之间的血小板聚集无显著差异。当饮食从低盐改为高盐后，两组在高脂 - 胆固醇饮食时的活性均显著增加。在低脂和高脂 - 胆固醇饮食下，有原发性高血压家族史的组因过量摄入盐导致平均血压显著升高，但无此家族史的组血压未升高。
