Reynolds C F, Kupfer D J, McEachran A B, Taska L S, Sewitch D E, Coble P A
J Clin Psychiatry. 1984 Jul;45(7):287-90.
Depression has been reported to be frequent in sleep apnea syndromes. In a sample of 25 consecutive male sleep apneics, 40% met Research Diagnostic Criteria for an affective disorder or for alcohol abuse. A multiple regression analysis indicated that 61% of the variance in depression ratings could be explained by four variables: age, REM activity, REM latency (square root), and presence or absence of antihypertensive medications (multiple R = 0.78). The use of these variables in a discriminant function analysis correctly predicted the membership of 68% of the sample in either a low or high depression group (kappa = 0.44; p less than .01). These findings are reviewed in relation to other research on age-related sleep changes and vulnerability to depression.
据报道，抑郁症在睡眠呼吸暂停综合征中很常见。在连续25名男性睡眠呼吸暂停患者的样本中，40%符合情感障碍或酒精滥用的研究诊断标准。多元回归分析表明，抑郁评分中61%的方差可以由四个变量解释：年龄、快速眼动（REM）活动、REM潜伏期（平方根）以及是否使用抗高血压药物（多元相关系数R = 0.78）。在判别函数分析中使用这些变量，正确预测了68%的样本属于低抑郁组或高抑郁组（kappa = 0.44；p <.01）。结合其他关于年龄相关睡眠变化和抑郁症易感性的研究对这些发现进行了综述。
