母血清和脐带血清中的抗病毒抗体：发现非特异性抑制剂在循环的母体一侧滴度更高。
Antibody against viruses in maternal and cord sera: non-specific inhibitors are found to higher titre on the maternal side of the circulation.
作者信息
Griffiths P D, Girdhar D, Fisher-Hoch S, Race M W, Heath R B
出版信息
J Hyg (Lond). 1984 Jun;92(3):297-301. doi: 10.1017/s0022172400064536.
Pregnancies were identified in which maternal IgG antibodies against rubella virus were not detectable by single radial haemolysis. Twenty paired maternal/cord sera were then tested for haemagglutination-inhibiting (HI) activity against rubella virus without kaolin pretreatment of the sera. In the absence of specific antibody, the HI activity observed could thus be ascribed to the effect of non-specific inhibitors. The HI activity in maternal sera was significantly (P less than 0.001) higher than that in cord sera. The 20 pairs of sera were similarly tested against a bunyavirus, an alphavirus and a flavivirus, both with and without kaolin pretreatment. The results showed non-specific inhibitors were found to higher titre in maternal sera, with the difference being statistically significant (P less than 0.001) for each of the three viruses.
识别出一些妊娠情况，其中通过单向辐射溶血法检测不到母体针对风疹病毒的IgG抗体。然后对20对母血/脐血血清进行检测，以检测其对风疹病毒的血凝抑制（HI）活性，血清未经高岭土预处理。因此，在没有特异性抗体的情况下，观察到的HI活性可归因于非特异性抑制剂的作用。母体血清中的HI活性显著高于脐血血清（P<0.001）。对这20对血清同样进行了针对布尼亚病毒、甲病毒和黄病毒的检测，检测时血清均经过和未经过高岭土预处理。结果显示，在母体血清中发现非特异性抑制剂的滴度更高，对于这三种病毒中的每一种，差异均具有统计学意义（P<0.001）。
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