聚d(G-T)双螺旋中的碱基配对结构：摆动碱基对。
Base pairing structure in the poly d(G-T) double helix: wobble base pairs.
作者信息
Early T A, Olmsted J, Kearns D R, Lezius A G
出版信息
Nucleic Acids Res. 1978 Jun;5(6):1955-70. doi: 10.1093/nar/5.6.1955.
Abstract
High resolution nuclear magnetic resonance (NMR) and ethidium bromide binding studies are used to demonstrate that poly d(G-T) forms an ordered double helical structure at low temperatures (below 24 degrees C in 0.3 M NaCl) in which G and T are hydrogen bonded together in a wobble base pair hydrogen bonding scheme as proposed earlier by Lezius and Domin. Alternative hydrogen bonding schemes involving the tautomeric form of either T or G, such as have been proposed to account for mutation rates in DNA synthesis, are eliminated.
摘要
高分辨率核磁共振（NMR）和溴化乙锭结合研究被用于证明聚d（G-T）在低温（0.3M NaCl中低于24摄氏度）下形成有序的双螺旋结构，其中G和T按照Lezius和Domin之前提出的摆动碱基对氢键模式通过氢键结合在一起。涉及T或G互变异构形式的其他氢键模式（例如已被提出用于解释DNA合成中的突变率）被排除。
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