Yangco B G, TeStrake D, Okafor J
Mycopathologia. 1984 May 30;86(2):103-11. doi: 10.1007/BF00436495.
A dematiaceous fungus, Phialophora richardsiae (Nannf.) Conant, was isolated from human bone. In culture the fungus produced no yeast forms and was less pigmented than two other P. richardsiae isolates. While growth rates were similar, colonial forms differed. Phialides were of two kinds. While both had broad bases and tapered at the tips, only one terminated with a cupulate or rarely a saucer-shaped collarette. Most phialides were hyaline with a few lightly pigmented ones in older cultures. Broth dilution susceptibility testing of the isolates against amphotericin B, miconazole, ketoconazole, clotrimazole, and 5-fluorocytosine showed the fungus was susceptible to miconazole, ketoconazole and amphotericin B at achievable serum levels and resistant to 5-fluorocytosine and clotrimazole. The other isolates were reported to differ in their resistance to miconazole and amphotericin B. Enzyme and salinity studies showed minor difference among the isolates.
从人骨中分离出一种暗色真菌，即理查兹瓶霉（Phialophora richardsiae (Nannf.) Conant）。在培养过程中，该真菌不产生酵母形态，且色素沉着比另外两株理查兹瓶霉分离株少。虽然生长速率相似，但菌落形态不同。瓶梗有两种类型。两者都基部宽阔，顶端逐渐变细，但只有一种末端有杯状或很少见的碟状衣领状结构。大多数瓶梗是透明的，在较老的培养物中有少数轻度色素沉着的瓶梗。对这些分离株进行的针对两性霉素B、咪康唑、酮康唑、克霉唑和5-氟胞嘧啶的肉汤稀释药敏试验表明，该真菌在可达到的血清水平下对咪康唑、酮康唑和两性霉素B敏感，对5-氟胞嘧啶和克霉唑耐药。据报道，其他分离株对咪康唑和两性霉素B的耐药性有所不同。酶和盐度研究表明，这些分离株之间存在微小差异。
