Lagendijk J J, Schellekens M, Schipper J, van der Linden P M
Phys Med Biol. 1984 May;29(5):495-507. doi: 10.1088/0031-9155/29/5/002.
A three-dimensional finite difference computer model has been developed to calculate temperature distributions in vascularised tissues in hyperthermia. Besides offering the possibility of calculating temperature distributions according to the conventional ' bioheat transfer' method, this model allows the introduction of several discrete blood vessels and can describe their influence on the temperature distribution. The model can be used to evaluate all types of heating techniques. First calculations on discrete large vessels show inhomogeneities caused by these vessels in the temperature distribution in tissue in hyperthermia. The theory and model presented can form the basis of a new bioheat transfer theory, with a vessel-temperature related bioheat transfer heat-sink term able to describe the small-scale temperature variation problems in local hyperthermia.
已经开发了一种三维有限差分计算机模型，用于计算热疗中血管化组织的温度分布。除了能够根据传统的“生物热传递”方法计算温度分布外，该模型还允许引入多个离散血管，并能描述它们对温度分布的影响。该模型可用于评估所有类型的加热技术。对离散大血管的初步计算表明，热疗中这些血管会导致组织温度分布不均匀。所提出的理论和模型可以形成一种新的生物热传递理论的基础，其中与血管温度相关的生物热传递热沉项能够描述局部热疗中的小尺度温度变化问题。
