Dybdahl J H, Haug K, Bakkevold K, Olsen K O, Vetvik K
Scand J Gastroenterol. 1984 May;19(3):343-9.
A total of 754 persons statistically selected from the age group 54-64 years were asked by letter to provide faecal samples for screening of occult blood during dietary restrictions. A total of 413 persons (55%) returned an average of 5.8 (range, 1-6) faecal samples each. All the faecal specimens were analysed with Hemoccult II slides and the 3,3',5,5'-tetramethylbenzidine (TMB) test 0.10%. For technical reasons, however, the Hemoccult test could not be evaluated. The TMB test showed faecal blood in 50 persons. A case history was obtained in 49 persons, of whom 47 agreed to further clinical, radiological, and endoscopic investigations. The most important findings in these examinations were resectable colonic carcinoma (Dukes's stage B) in 1 subject, a gastric ulcer in 1, haemorrhagic gastritis in 1, duodenal ulcers in 2, and colorectal polyps in 11 persons. The cost of the study was estimated to be NOK 114,000 (about USD 16,000).
通过信函邀请从54至64岁年龄组中按统计学方法选取的754人，在饮食限制期间提供粪便样本以筛查潜血。共有413人（55%）回复，每人平均提供了5.8份（范围为1至6份）粪便样本。所有粪便标本均使用Hemoccult II载玻片和0.10%的3,3',5,5'-四甲基联苯胺（TMB）试验进行分析。然而，由于技术原因，无法对Hemoccult试验进行评估。TMB试验显示50人粪便潜血阳性。对其中49人进行了病史采集，其中47人同意进一步进行临床、放射学和内镜检查。这些检查中最重要的发现包括：1例可切除的结肠癌（杜克分期B期）、1例胃溃疡、1例出血性胃炎、2例十二指肠溃疡以及11例大肠息肉。该研究的成本估计为114,000挪威克朗（约合16,000美元）。
