Mobarak N, P'an A Y
Toxicology. 1984 Jul;32(1):67-74. doi: 10.1016/0300-483x(84)90035-0.
Sprague-Dawley rats were treated with 1, 2 or 3 i.p. injections of lead acetate (100 mg/kg) and sacrificed 24 h, 3 days, 7 days, 14 days and 21 days after the last injection. Lead concentration was determined by flameless AAS technique in whole blood, plasma, plasma filtrate, saliva and submaxillary gland tissue. The concentration of lead in saliva was about 5% of whole blood lead concentration and around 61% of plasma filtrate lead level. Saliva lead concentration was significantly related both to whole blood lead concentration and plasma filtrate lead concentration (r = 0.78, P less than 0.001; r = 0.80, P = 0.001 respectively). Lead was present in the submaxillary gland tissue; the amount of lead increased with increasing amounts administered.
将Sprague-Dawley大鼠腹腔注射1、2或3次醋酸铅（100毫克/千克），并在最后一次注射后的24小时、3天、7天、14天和21天处死。采用无火焰原子吸收光谱技术测定全血、血浆、血浆滤液、唾液和颌下腺组织中的铅浓度。唾液中的铅浓度约为全血铅浓度的5%，约为血浆滤液铅水平的61%。唾液铅浓度与全血铅浓度和血浆滤液铅浓度均显著相关（r分别为0.78，P<0.001；r为0.80，P=0.001）。颌下腺组织中存在铅；铅的含量随着给药量的增加而增加。
